Naturally plants are exposed with many adverse environmental conditions like biotic and abiotic stress. Despite all other stresses, heavy metal stress is one of great importance which has a notable adverse effect on crop productivity and growth. Agricultural crops also have the ability to uptake the heavy metals through their roots and transport them to the edible portions of the plant that are consumed by people or fed to animals. Their increased concentration in human food chain over a long time can provoke detectable damage to health (carcinogenic and mutagenic effect). Based on this study report, it was observed that lead and nickel concentration produced toxic impact on growth of Vigna radiata (L.) and brought the changes in growth parameters and decreased the content of proline, protein, chlorophyll and phenolic compounds.