Current Issue (In Progress)

Volume -11, Issue - 3,  March 2025


Development of Cell Targeted Drug Delivery (CTDD) using Hyaluronic Acid-Antimicrobial Drug Conjugation
Authors : Riaz   Khan, Vincent   Aroulmoji, Mani   Mohan,

https://doi.org/10.29294/IJASE.11.3.2025.4111-4115

Our research on the development of Cell Targeted Drug Delivery (CTDD) Conjugation Technology based on Hyaluronic acid (HA), a naturally occurring polysaccharide uniquely involved in biological processes, was initiated in 1998, in the Institute of POLYbios, AREA Science Park, Trieste, Italy. The fundamental aspects of the chemistry of HA and its significance in drug delivery were explored.... Read More

Enhancing Molecular Electronic Property Analysis: A Gauss Shiny Application for Gaussian Log Processing
Authors : Tamil Bharathi   Viswanathan, Gnanendra   Shanmugam, Vincent   Aroulmoji,

https://doi.org/10.29294/IJASE.11.3.2025.4116-4119

Computational chemistry relies heavily on quantum mechanical calculations to predict molecular properties. Gaussian, widely used quantum chemistry software generates log files containing crucial electronic parameters. However, manually extracting and analyzing these properties is time-consuming and prone to errors. We present an R Shiny application that automates the extraction and computation... Read More

Optimized structure, Topology, Hirshfeld surface and Molecular docking analysis of some Pregnane derivatives
Authors : Neha   Kumari, Rajni   Kant,

https://doi.org/10.29294/IJASE.11.3.2025.4120-4130

Pregnane, 17β- ethylandrostane, a C21 crystalline steroid, is indirectly a parent of progesterone. Its derivatives show some interesting biological properties. Thus, an attempt has been made to identify a few structures from the CSD database (version: 2023) for their detailed crystallographic and computational analysis. The X-ray structures have been compared with their corresponding optimized... Read More

Synthesis of Silver Nanoparticles using Mixed Plant Extract for Antibacterial and Catalytic Applications
Authors : Swati K.   Patil , Shivanand B.   Telia, Kiran S.   Dhanavade, Renuka A.   Pawar, Kalyanrao M.   Garadkar,

https://doi.org/10.29294/IJASE.11.3.2025.4131-4149

One of the most important concern in the 21st century is the demand for the green technology for the preparation of nanomaterials. This work presents the fabrication of green silver nanoparticles (AgNPs) with a combined plant leaf extract such as Azadirachta indica and Mangifera indica L. The mixture of leaf extract acts as a reducing and stabilizing agent. The presence of many phytochemicals in... Read More

Evaluation of Drought Tolerant near Isogenic Lines of  ADT37 Rice Variety (Oryza sativa L.) at Physiological and  Anatomical Level
Authors : P.   Vignesh, M.   Karthika, P.C.   Obli Prakash, M.   Maghimaa, Selvaraj   Jagannathan, S.   Bharathkumar,

https://doi.org/10.29294/IJASE.11.3.2025.4150-4163

Rice (Oryza sativa L.) is a crucial global food crop, although it is extremely susceptible to drought stress owing to its adaption to wetland environments. This study assessed nine enhanced rice lines possessing qDTY3.1 and qDTY2.1, significant quantitative trait loci (QTLs) for drought resistance during the flowering stage, under both flooded and drought stress conditions. The experiment was... Read More

Synthesis of Biogenic Silver Nanoparticles using  Phyllanthus niruri Extract for Photocatalytic Dye Degradation and Antifungal Applications
Authors : Menakshisundaram Balasubramaniam   Lithesh, S.   Vidya Saranya, Monisha   Prasad, Vinitha   Packirisamy,

https://doi.org/10.29294/IJASE.11.3.2025.4164-4174

Biogenic nanoparticles synthesis is gaining more attention from researchers due to its eco-friendly and biocompatible nature. In this study, we report an easy and green method for silver nanoparticle preparation using the leaf extract of Phyllanthus niruri. The constituents of PN extract act as reducing and capping agents. The formation of PN-AgNPs was confirmed by UV-Vis Spectroscopy which... Read More

Molecular Insights of Hyaluronic Acid-Molnupiravir Conjugate as a New Drug in Targeting SARS-CoV-2 Viral Proteins
Authors : R.   Thirumalaisamy, M.   Mohan, V.   Aroulmoji, K.   Deepakvijay, P.   Rekha, Kishore   Tariq, Kalandar   Ameer, Riaz   Khan,

https://doi.org/10.29294/IJASE.11.3.2025.4175-4195

The antiviral drug Molnupiravir (MOL) and its conjugate with Hyaluronic Acid (HA-MOL) demonstrate the significance of targeting the main protease (Mpro) and papain-like protease (PLpro) of SARS-CoV-2. The pure drug Molnupiravir and the designed polymer-drug conjugate using Molnupiravir and hyaluronic acid were evaluated through molecular docking, pharmacokinetic analysis, molecular dynamics... Read More

Evaluation of Antibacterial, Antioxidant and  Anti-inflammatory Potential in the Methanolic Extract of Caulerpa racemosa Marine Algae
Authors : Senthilraj   Rajapandi, Magesh   Mohan, Deepika   Devaraj, Gokul raj   Gopinath, Sudharsan   Peroumal, Vijaya Kishore   Kanakaraju, Madhuri Latha   Thadanki,

https://doi.org/10.29294/IJASE.11.3.2025.4196-4205

Marine organisms, particularly algae, have garnered significant attention due to their rich biodiversity and potential as sources of novel bioactive compounds. Among them, Caulerpa racemosa, a green alga commonly found in tropical marine environments has been recognized for its therapeutic potential, but its biological activities remain underexplored. The current study investigates the... Read More

Emerging Threat of Food Contamination by Microplastics and its Influence on Safety and Human Perspective
Authors : S.   Bharath, M.   Maghimaa, T.   Selvankumar,

https://doi.org/10.29294/IJASE.11.3.2025.4206-4222

Extensive plastic use across industries such as automotive, construction, and packaging has significantly contributed to environmental concerns. Understanding the sources of microplastic contamination in food and its associated health risks is crucial for minimizing exposure. As a result, this issue has gained attention due to its potential negative impact on human health. Food contamination... Read More

QBD Driven Bioanalytical Method Development and Validation of Tepotinib using RP-UPLC
Authors : Bonagiri   Pavani, Narender   Malothu, Areti Anka   Rao, Chakravarthi   Guntupalli,

https://doi.org/10.29294/IJASE.11.3.2025.4223-4236

The research aims to establish a new UPLC method for estimating Tepotinib in human plasma. A simple, precise, and accurate RP-UPLC technique has been developed to quantify Tepotinib (TEP) in human plasma by employing a Quality by Design (QbD) approach. The effective separation of TEP was accomplished using the ACQUITY UPLC HSS C18 Column (1.8 µm, 2.1 mm×100 mm) and 0.01N Ammonium formate :... Read More

Lactotransferrin Peptide: A Promising Inhibitor of Streptococcus Mutans Biofilm and Virulence
Authors : Manikandan   Janani, M.   Maghimaa, Rajamanickam   Usha,

https://doi.org/10.29294/IJASE.11.3.2025.4237-4256

Dental caries, the most common chronic infectious disease in the oral cavity, affects around 3.5 billion individuals worldwide, with a particularly high prevalence in middle-income countries. Streptococcus mutans is a major cariogenic pathogen recognized for its ability to form biofilms that lead to tooth decay. Molecular docking studies showed stable interactions between lactotransferrin (LTF)... Read More