The present study evaluated the potential of chitosan-assisted phytocompounds from Centella asiatica for antibacterial food packaging application. Chitosan, a natural polymer, is widely explored for its biocompatibility, biodegradability, and inherent antibacterial qualities, making it suitable for developing delivery systems that enhance plant-derived compound stability, bioavailability, and controlled release. GC-MS analysis of the aqueous leaf extract identified seven major compounds, with 2-chloro-6-fluorophenol showing the highest abundance (56.71%). SEM imaging revealed amorphous, irregularly shaped particles with optimized crystallite formation. Antioxidant assays (DPPH and ABTS) confirmed significant free radical scavenging activity, with IC50 values of 14.60 and 9.2 µg/ml, respectively. Strong antibacterial action was also observed against E. coli, Salmonella typhi, Klebsiella pneumoniae, and Pseudomonas aeruginosa, with inhibition zones ranging from 16–21 mm. In food packaging trials, coated samples retained their original color, texture, and taste with no spoilage, highlighting the dual therapeutic and preservative potential of this composite system.
