The global incidence of dengue fever, transmitted primarily by the mosquito Aedes aegypti, continues to rise, prompting the urgent need for effective and sustainable vector control strategies. This study investigates the potential of potent phytomedicines derived from five medicinal plants Melia dubia, Azadirachta indica (neem), Adhatoda vasica (vasaka), Solanum nigrum (black night shade) and Aegle marmelos (bael), as natural alternatives to synthetic insecticides for dengue vector management. These plants were selected for their well-documented insecticidal properties and historical use in traditional medicine. Our research focused on evaluating the larvicidal activity of extracts from these plants against Aedes aegypti under controlled laboratory conditions. The larvicidal assays demonstrated significant mortality rates, with these extracts showing over 90-100% larval mortality at diverse concentrations. Our findings underscore the importance of these botanical extracts as viable, eco-friendly alternatives to chemical insecticides. The integration of such phytomedicines in dengue vector control programs could reduce the reliance on synthetic chemicals, mitigate environmental and health impacts, and address issues of insecticide resistance. Further studies on field efficacy, formulation optimization, and safety profiles are recommended to advance these phytomedicines toward practical applications in public health initiatives.
