The main goal in the drug delivery strategy exploiting nucleic acid based drugs (NABDs) is the capability to target the desired sequence of nucleic acid into the selected cell using appropriate polymeric carriers. The field of application of this technology regards the modification of the expression pattern mainly in tumour cells. The present work aims at developing a feasible methodology for the synthesis of a nucleic acid delivery system based on hyaluronic acid, a biopolymer carrier actively taken up by the cells through specific molecular surface receptors.
