The synthetic phenolic antioxidants (SPAs) are widely used as an additives in food, cosmetic and plastic industries to increase the tenability. These antioxidants are degraded into mammals, yet as into the environment like river and water. for instance the common intake of BHT (butyl hydroxytoulene) i.e. one among the kinds of SPAs (synthetic phenolic antioxidants) being is estimated to be 0.3 mg/kg weight, while it absolutely was considered as safe for human at authorized level, but it’s ubiquitous presence within the aquatic environment and its controversial toxicological data are of great concern for human similarly as aquatic life. This study summarizes both the synthetic and natural phenolic antioxidants, mainly emphasizing their mode of action, health effects, degradation products and toxicology. Zebrafish (Danio rerio) has proved to be a wonderful vertebrate organism for analyzing various developmental stages, decreasing model, and screening of drug toxicities thanks to their minuscule, high fecundity, optical transparency, and their close resemblance with the genome of the creature.