Data Mining is one of the most motivating areas of research that is become increasingly popular in health organization. In this paper, we present a brief introduction and focused to compare a variety of techniques, approaches and different tools and its impact on the healthcare sector. The Data Mining plays an important role for uncovering new trends in healthcare organization which in turn that data are facts, numbers, or text which can be processed by a computer into knowledge or information. Also presents a comparative study of different data mining applications, techniques and different methodologies applied for extracting knowledge from database generated in the healthcare industry.