Modern high-rise structures frequently employ open ground floors sustained by floating columns to optimize usable area and improve aesthetics. This design, however, produces vertical flaws that diminish seismic performance. This research examines the seismic performance of G+9 reinforced concrete (RC) frame structures, both with and without floating columns, utilizing STAAD Pro and Response Spectrum Analysis (RSA) in accordance with IS 1893:2016 and IS 456:2000 standards. The research evaluates parameters like storey displacement, base shear, bending moment, shear force, and torsion. Results indicate that structures with floating columns demonstrate a 3–8% increase in storey displacement and increased torsional impacts due to interrupted load transmission mechanisms. These constructions exhibit increased vulnerability to seismic damage, particularly at the floating column level. The study indicates that floating columns should be avoided in seismic zones or planned symmetrically with larger columns and supplementary shear walls to enhance stability while preserving architectural flexibility.