Bacterial infections are becoming intricate in dental therapy due to the rise of antibiotic resistant pathogens. Promising therapeutic candidates as alternatives to antibiotics may include antimicrobial peptides (AMPs) derived from bacteria, plants, animals, milk products and synthetic sources. This study investigates the therapeutic potential of antimicrobial peptides (AMPs) as alternatives to traditional antibiotics for treating dental infections, including periodontitis, dental caries, and endodontic infections. AMPs are multifunctional innate immune molecules that play essential roles in disrupting membrane integrity, defending against pathogens, regulating immune responses and make them promising alternatives to traditional antibiotics. This study emphasizes the antimicrobial efficacy, biocompatibility, and mechanism of action of AMPs against key oral pathogens. AMPs as next-generation therapeutics in dentistry due to their potent antimicrobial activity, biofilm penetration, low resistance risk, and regenerative properties. It is a transformative tool in overcoming limitations of traditional dental antibiotics. AMPs offer a promising solution to the growing crisis of antibiotic resistance among oral pathogens. Their membrane-targeting action, and low tendency to induce resistance make them ideal candidates for replacing antibiotics in dental infections. Future dental kits may combine AMPs with conventional agents for dual-mechanism therapy. AMP-embedded materials will provide continuous antimicrobial protection and improved long-term outcomes.
