The synthesis of metal and semiconductor nanoparticles is an expanding research area due to the potential applications for the development of novel technologies. There is an increasing commercial demand for nanoparticles due to their wide applicability in various fields such as electronics, catalysis, chemistry, energy, and medicine. One of the major challenges of current nanotechnology is to develop rapid and reliable experimental protocols for the synthesis of nanoparticles over a range of chemical compositions that must also be non-toxic, clean and eco-friendly, by using ambient biological resources. In this study was carried out the simple biological synthesis of silver nanoparticles by the reaction of aqueous silver nitrate with fresh and shade dried leaf extracts common weeds such as Lantana camera and Leucas aspera at room temperature. The formation of silver nanoparticles was also confirmed by spectrophotometric determinations at various incubation periods in different pH environments. UV-vis and FTIR spectroscopy results showed that leaf extracts of Lantana camera and Leucas aspera are having good potential for synthesis silver nanoparticles under controlled pH conditions. The present study is provided a new avenue for utilization of this obnoxious weed plant species and making it as value added plants for nanotechnology based industries in near future.