This study focuses on smart functionalization of protein fabric preparation by using the synergistic antimicrobial agents like expired antibiotic drug amoxicillin. Protein fabrics like wool and silk containing different groups of amino acids, has been pre-treated with expired drug amoxicillin and chitosan at various concentrations (1%, 2%, 3% OWF) (to impart antimicrobial/antibacterial properties to fabric). The modified wool or silk fabric was then dyed with four different acid dye using exhaust method in a Rota dyer. The colour strength value and K/S value were evaluated by using spectrophotometer and the antimicrobial activity is evaluated by using the AATCC 147 test method. The above dyed samples have shown good washing, light fastness properties with high depth of colour value. The pre treated wool and silk fabrics were coated with Amoxicillin along with chitosan have shown an excellent antimicrobial activity. Amoxicillin attaches to the cell wall of susceptible bacteria and inhibit the growth of bacteria results in their death. The antibiotic coating is effective against streptococci, pneumococci, enterococci, Haemophilusinfluenzae, Escherichia coli, Proteus mirabilis, Salmonella, Borreliaburgdorferi, and Helicobacter pylori. The presence of chitosan is further enhanced both by increasing the rate of dye uptake as well as inhibit the growth of micro organism
