Volume -11, Issue -4  Jun 2025


 Green Synthesis and Characterization of Copper Oxide Nanoparticles using Cassia auriculata and their Antioxidant and Antibacterial Properties
Authors : Magesh Mohan,Sudharsan Peroumal,Gokul Raj Gopinath,Deepika Devaraj,Chinnasamy Ragavendran,

https://doi.org/10.29294/IJASE.11.4.2025.4392-4404

Green nanotechnology has become more popular in recent years to produce metallic nanoparticles since it is inexpensive, requires few preparatory processes, and is sustainable. The current work used Cassia auriculata L. leaf extract to effectively green-synthesize copper nanoparticles (CuO NPs). The generated CuO nanoparticles were properly characterized through UV-Vis, FT-IR, FE-SEM, and EDX...

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A Brain Tumor Classification of Feature Extraction Using Hybrid Dictionary Learning Algorithm and Spider Optimization Neural Network
Authors : D. Sivakumar,P. Ramkumar,M. Selvi,T. Auntin Jose,S. Rajeshwari,

https://doi.org/10.29294/IJASE.11.4.2025.4405-4423

Brain tumors are a group of tissues formed by the continuous collection of irregular cells, and it is important to classify brain tumors for magnetic resonance imaging (MRI) treatment. Human examination is the standard for MRI detection of brain tumors and tumor tissue. Visualized image organizes the magnetic resonance image of the brain and provides various mechanisms depending on the body...

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Acute and Sub-Acute Toxicological Study of Short Chain  Fatty Acids (SCFAs) in Rats
Authors : P. Rajyalakshmi Devi,Mote Srinath,Talla Venu,Vinod Kumar Nelson,M. Vinyas,

https://doi.org/10.29294/IJASE.11.4.2025.4424-4434

The gut microbiota ferments undigested fiber to produce short-chain fatty acids (SCFAs) such as butyrate, acetate, and propionate. These play a crucial role in metabolic regulation, especially in obesity and diabetes. This study aimed to evaluate the potential toxic effects of SCFAs and LD50 following the IAEC 420 guidelines. Eighteen rats (150–250 g) were divided into three groups and...

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Enhancing Biological Activities of Chitosan/PVP Crosslinked Hydrogel Cube in Aqueous Solution
Authors : Madhumitha Kannan,Mohana Priya,H. Premkumar,Deepak Sharma,Arockia Alex,Vinay Kumar,

https://doi.org/10.29294/IJASE.11.4.2025.4435-4446

Hydrogel cubes are now considered essential instruments in medication delivery and release applications because of their distinct characteristics and adaptable capabilities. These polymer networks have a three-dimensional structure and are hydrophilic. They are very compatible with living organisms, allowing for controlled and continuous drug release, which is important for sustaining treatment...

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Innovative use of Fermented Mosambi Peel Liquid as a Sustainable Larvicide against Culex quinquefasciatus and Growth Promoter for Flora and Fauna
Authors : Shanmugavadivel Sangeetha,Mani Poonkothai ,

https://doi.org/10.29294/IJASE.11.4.2025.4447-4456

This study explores the sustainable production of mosambi peel liquid (MPL) through fermentation, emphasizing its larvicidal and growth-promoting potential. Physico-chemical characterization revealed its acidic nature, with quantification of acetic, citric, and tartaric acids. A larvicidal assay using MPL at 0.5%, 1%, 1.5%, and 2% concentrations against third instar larvae of Culex...

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Larvicidal Activity of Medicinal Plant Extracts against Dengue Vector Aedes aegypti
Authors : M. Maghimaa,Rajabalaji Vasudevan,B. Giridhar Aravind,M. Gayathri,

https://doi.org/10.29294/IJASE.11.4.2025.4457-4467

The global incidence of dengue fever, transmitted primarily by the mosquito Aedes aegypti, continues to rise, prompting the urgent need for effective and sustainable vector control strategies. This study investigates the potential of potent phytomedicines derived from five medicinal plants Melia dubia, Azadirachta indica (neem), Adhatoda vasica (vasaka), Solanum nigrum (black night shade) and...

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Analysis of Drug Tolerance in Ocular Pseudomonas aeruginosa Isolates
Authors : Vidyarani Mohankumar,Sangeetha Ramalingam,Lalitha Prajna,

https://doi.org/10.29294/IJASE.11.4.2025.4468-4475

Corneal infections caused by Pseudomonas aeruginosa result in severe visual disability, where the drug-sensitive isolates are often associated with worse clinical outcomes. We aimed to analyze the drug tolerance pattern among corneal P. aeruginosa isolates to fluoroquinolone and aminoglycoside antibiotics. Ten antibiotic-sensitive P. aeruginosa keratitis isolates were exposed to 100 µg/ml...

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Accurate Breast Cancer Diagnosis using Machine Learning
Authors : G. Meenalochini,D. Amuthaguka,

https://doi.org/10.29294/IJASE.11.4.2025.4476-4491

In today’s fast-paced world, lifestyle choices have substantially changed, influencing overall health. Among the various methods available for breast cancer screening, mammography remains the most widely used technique. Recent advancements have introduced computer-aided diagnostic systems that improve mammogram quality and assist in detecting suspicious regions. This paper aims to detect the...

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 Analyzing M/M/1 Working Vacation Model with Dual Server Breakdowns, Retrial Queue, and Interruptions: A Study on Classical Retrial Policies
Authors : M. Shanmugavalli,K. Majella Jenvi Ignatia,N. Vijaya,Gowri Senthil,S. Thalapathiraj,M. Helda Mercy,

https://doi.org/10.29294/IJASE.11.4.2025.4492-4504

This article examines two variants of the Working Vacation framework that are controlled by a Classical Retrial Policy. These variants include dual server failures and a retrial queue with disruptions during operational breaks .The long-run client distribution in a M/M/1 queue during operational breaks is determined using the matrix geometric method. Failures may arise in both the server's active...

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Fault Diagnosis in Analog Circuits Using an Integrated Swarm Optimization Framework
Authors : G. Puvaneswari,

https://doi.org/10.29294/IJASE.11.4.2025.4505-4517

Effective fault diagnosis is essential in sensitive applications like communication systems, medical devices, and aviation electronics. Traditional methods face limitations such as sensitivity to local minima, high complexity, and suboptimal test node selection. To overcome these, this research proposes a novel approach—Multi-Strategy Fault Diagnosis using Integrated Swarm Optimization...

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Effects of Composition on the Structural and Thermal Properties of PVC/PVDF-HFP Blends
Authors : Shivangi Shukla,Swarnim Patel,Purvee Bhardwaj,

https://doi.org/10.29294/IJASE.11.4.2025.4518-4525

In this work, pure PVC films and PVC-PVDF-HFP mix films were made utilizing the solution casting process with variable wt% of PVC to PVDF-HFP. FTIR, XRD, and DSC techniques were used to evaluate the structural, morphological, and miscibility properties of the films. FTIR and XRD data verified molecular interactions between the two polymers, highlighting the occurrence of the α-phase of PVDF-HFP...

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Bioethanol Production-Optimization of Consolidated Bioprocessing by Fungi and Yeast and its  Biomedical Applications
Authors : K. Sukirtha,Rajabalaji Vasudevan,M. Maghimaa,Karthikeyan Murugesan,Lali Growther,

https://doi.org/10.29294/IJASE.11.4.2025.4526-4542

This study primarily focuses on the technical and financial aspects of using acid pretreatment in bioethanol production from corn stover. The corn stover was treated with 2% diluted sulfuric acid and inoculated with Fusarium oxysporum to enhance saccharification efficiency. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were used to examine the corn...

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Energy Efficient Wireless Sensor Network with Hybrid Mutation Albatross Optimization Algorithm Based            Cluster Head Selection
Authors : Amsaveni Manigandan,M. Saranya,

https://doi.org/10.29294/IJASE.11.4.2025.4543-4556

The efficient management of energy resources remains a critical challenge in the operation of Wireless Sensor Networks (WSNs), where clustering is widely adopted to reduce energy consumption and extend network lifetime. A key factor in clustering efficacy is the optimal selection of cluster heads (CHs), as poor selection leads to excessive energy consumption due to disproportionate data...

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Effects of Injection Timing and EGR on Performance of CRDI Diesel Engine Fueled with Ceiba Pentandra Oil Methyl Ester (CPOME), 2-ethylhexyl nitrate and Diesel Blend
Authors : B. Karthikeyan,I. Maximas,S. Sathiya Narayanan ,

https://doi.org/10.29294/IJASE.11.4.2025.4557-4566

Diesel engines are highly fuel efficient compared to gasoline engines but due to environmental concerns and the depleting amount of petroleum reserves, the need of biofuel is unavoidable in present world. Biodiesel can be easily prepared by renewable stocks and non-toxic as well as it can be used in pure state or by blending with diesel in a conventional diesel engine without any major engine...

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Coupled Common Fixed-Point Theorems for Single-Valued Mapping via Generalized Coincidence Property in  Fuzzy Metric Space
Authors : Sushma Yadav,Kamal Wadhwa,Rashmi Tiwari,

https://doi.org/10.29294/IJASE.11.4.2025.4567-4577

The fixed-point theorem gives the conditions under which maps (single or multi-valued) have solutions. Fixed point theory itself is a mixture of analysis that is pure and applied, topology, and geometry. In the past 50 years, the theory of fixed points has come to show something that had been hidden as a very powerful and important tool in the study of non-linear phenomena. In fixed points in...

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Green Synthesis and Application of Nickel and Nickel–Lithium Oxide Nanocomposite as Cathodic Materials for  Lithium-Ion Batteries
Authors : M. Radhamani,V. Aroulmoji,S. Poongodi,M. Mohan,V. Hariharan,

https://doi.org/10.29294/IJASE.11.4.2025.4578-4590

The present study reports the successful green synthesis of Nickel (Ni) and Nickel–Lithium Oxide (Ni–Li₂O) composite nanoparticles. Powder X-ray diffraction (XRD) analysis confirmed the formation of both Ni and Ni–Li₂O composite nanoparticles with a Face-Centered Cubic (FCC) crystal structure. The average crystallite size of the Nickel nanoparticles was found to be 37.97 nm, while that...

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Natural Fibers Reinforced Polymer Composite: Focus on Mechanical, Tribological and Biodegradable Properties
Authors : Mr. Govinda,Chingakham Chinglenthoiba,Jitendra Kumar Katiyar,

https://doi.org/10.29294/IJASE.11.4.2025.4591-4609

Interest in creating sustainable materials, such as natural fiber-reinforced polymer composites, for various industrial applications has increased due to the depletion of petroleum resources and environmental concerns. Natural fibers are strong and enhance the mechanical strength of polymer matrices through their inherent strength, adhesion to polymers, effective load transfer, damping...

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Characterization and Molecular Docking Study of Biodegradable Thin Films Synthesized from Basil and Fenugreek Seeds Mucilage for Anti-diabetic Activity
Authors : Vanitha Arumugam,Mani Mohan,Vennila Raj,S. Gracelin Juliana,Rekha Pachaiappan,

https://doi.org/10.29294/IJASE.11.4.2025.4610-4627

Recent year’s research works have shown improvement in the development of biodegradable films from greens. They are helpful in the production of edible products related to human health and food packaging applications. Herbal drugs, products, and remedies have been valued for their medicinal qualities that are useful in several biomedical applications. Research community aims to develop the...

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 Exploration and Validation of Antimicrobial Phytocompounds for Multi-Drug Resistance from Eclipta alba through                   In Vitro and In Silico Approaches
Authors : Suresh Thanjavur Mani,Subramanian Ammashi,R. Thirumalaisamy,S. Parvathy,M. Abareethan,P. Vadivel,K.S. Shalini,T. Selvankumar,

https://doi.org/10.29294/IJASE.11.4.2025.4628-4652

Plant derived compounds show promise in addressing multi-drug resistance (MDR) in pathogens. This study evaluates Eclipta alba ethanolic extract for anti-MDR activity through integrated in vitro and in silico approaches. Phytochemical screening revealed abundant alkaloids, flavonoids, saponins, terpenoids, phenols, coumarins, and steroids, with quantified flavonoids (8.21 ± 0.53 mg QE/g) and...

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Modeling the Effects of Ultra-Low Dose Hormone Therapy on Bone Health in Postmenopausal Women: A Mathematical Shock Model Based Analysis
Authors : M. Shanmugavalli,K. Majella Jenvi Ignatia,S. Thanikaikarasan,

https://doi.org/10.29294/IJASE.11.4.2025.4653-4665

This study examines the effects of ultra-low-dose hormone therapy (Ultra-LD HT) on bone turnover in postmenopausal women through the lens of a mathematical shock model. In this framework, intermittent physiological stressors such as fluctuations in bone remodeling dynamics or estrogen depletion are conceptualized as mathematical shocks occurring in a Poisson pattern. These shocks model sudden,...

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Influence of Heater Length and Positions on Buoyant Convection of Micropolar Fluid in an Enclosure
Authors : C. Manjula,V. Sivakumar,S. Sivasankaran,

https://doi.org/10.29294/IJASE.11.4.2025.4666-4678

This study analyzes the convection heat transfer to a micropolar fluid in an enclosure with varied heating lengths and locations. The left wall is heated to higher temperatures, either fully or partially, while the right wall remains cooler. The heater is placed at three different positions along the left wall, and insulation is applied to the non-active areas. Using the finite volume method,...

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Exploration and Validation of Thrombolytic Phytocompounds from Curcuma amada Roxb through In Vitro and        In Silico Approaches
Authors : Mariappan Srilatha,Vincent Aroulmoji,Thirumalaisamy Rathinavel,C. Roumana,Mohan Hariharan,Meganathan Bhuvaneswari,Subramanian Ammashi,Ramalingam Karthik Ramalingam Karthik Raja,

https://doi.org/10.29294/IJASE.11.4.2025.4679-4702

The present study aims to assess antioxidant and thrombolytic efficacy of Curcuma amada Roxb. (Mango ginger) rhizome extracts terpenoid and phenolic compounds as new therapeutic prospects to serve as fibrinolytic agents. Curcuma amada extract was fractioned with different solvents based on polarity by using pure methanol, ethanol, hydro ethanol, and water. Preliminary phytochemical analysis of...

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Green Nanoparticles from Solanum nigrum: Proteomic Analysis of Their Effects on Human Gastric Cancer Cells
Authors : Kaavya Unni,S. Antony,

https://doi.org/10.29294/IJASE.11.4.2025.4703-4723

Solanum nigrum, commonly known as black nightshade, is abundant in temperate and subtropical regions and is rich in bioactive compounds, including alkaloids, flavonoids, and saponins, which exhibit notable antimicrobial and anticancer properties. With advancements in nanotechnology, silver nanoparticles (AgNPs) have garnered significant attention due to their unique biological activities. In...

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Enhanced Low-resolution Face Recognition through Bidirectional GRU with Attentional Focus
Authors : Pranali Dandekar,Shailendra S. Aote,Abhijeet Raipurkar,

https://doi.org/10.29294/IJASE.11.4.2025.4724-4734

Low-resolution face recognition (LRFR) remains a challenging task due to the loss of critical facial details and the domain gap between high-resolution (HR) and low-resolution (LR) images. In this paper, we propose a novel architecture based on a Bi-directional Gated Recurrent Neural Network with an Attention Mechanism (BiGRU-AM) to address these challenges. The model was trained and validated...

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IGDTMC- Information Gain Decision Tree Matrix Classifier for Software Metrics Evaluation in Open Source Software
Authors : T. Arun Nehru,V. Sangeetha,

https://doi.org/10.29294/IJASE.11.4.2025.4735-4744

This paper proposes an Information Gain (IG) -Decision Tree Matrix (DTM) Classifier (IG-DTMC) method for open-source code, which improves accuracy by optimizing the selection of software metrics. For the software metric subset selection, a subset of metrics is collected by the application of the IG model. Here, the relevant and irrelevant metrics are separated by the using those gathered subset...

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Proteomics Approach Revealing Molecular Mechanism behind the Antibacterial Activity of Terminalia chebula in Staphylococcus aureus
Authors : Neethu Sudarsan,T.A. Hema,

https://doi.org/10.29294/IJASE.11.4.2025.4745-4762

Patients with long-term diabetes often develop Diabetic Foot Ulcers (DFUs), which are prone to infections that can lead to severe complications, including antibiotic resistance. This study explores the antibacterial potential of Terminalia chebula fruit extracts against Staphylococcus aureus by comparing protein expression in treated and untreated bacterial cells. The analysis revealed...

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Integrating Artificial Intelligence into Modern Water Management Frameworks: Review
Authors : Naseera Kannanthodi Pariyapurath,R. Tarunprasad,M. Maghimaa,Selvaraj Jagannathan,Reshma Muthuvel,

https://doi.org/10.29294/IJASE.11.4.2025.4763-4774

Water is essential for all forms of life and plays an important role in various aspects of human existence. Water management is essential for addressing water-related challenges, promoting sustainable development, protecting the environment, and ensuring the well-being of communities worldwide. Artificial Intelligence (AI) has become a revolutionary technology in the realm of water treatment,...

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