Our research on the development of Cell Targeted Drug Delivery (CTDD) Conjugation Technology based on Hyaluronic acid (HA), a naturally occurring polysaccharide uniquely involved in biological processes, was initiated in 1998, in the Institute of POLYbios, AREA Science Park, Trieste, Italy. The fundamental aspects of the chemistry of HA and its significance in drug delivery were explored.... Read More

Computational chemistry relies heavily on quantum mechanical calculations to predict molecular properties. Gaussian, widely used quantum chemistry software generates log files containing crucial electronic parameters. However, manually extracting and analyzing these properties is time-consuming and prone to errors. We present an R Shiny application that automates the extraction and computation... Read More

Pregnane, 17β- ethylandrostane, a C21 crystalline steroid, is indirectly a parent of progesterone. Its derivatives show some interesting biological properties. Thus, an attempt has been made to identify a few structures from the CSD database (version: 2023) for their detailed crystallographic and computational analysis. The X-ray structures have been compared with their corresponding optimized... Read More

One of the most important concern in the 21st century is the demand for the green technology for the preparation of nanomaterials. This work presents the fabrication of green silver nanoparticles (AgNPs) with a combined plant leaf extract such as Azadirachta indica and Mangifera indica L. The mixture of leaf extract acts as a reducing and stabilizing agent. The presence of many phytochemicals in... Read More

Rice (Oryza sativa L.) is a crucial global food crop, although it is extremely susceptible to drought stress owing to its adaption to wetland environments. This study assessed nine enhanced rice lines possessing qDTY3.1 and qDTY2.1, significant quantitative trait loci (QTLs) for drought resistance during the flowering stage, under both flooded and drought stress conditions. The experiment was... Read More

Biogenic nanoparticles synthesis is gaining more attention from researchers due to its eco-friendly and biocompatible nature. In this study, we report an easy and green method for silver nanoparticle preparation using the leaf extract of Phyllanthus niruri. The constituents of PN extract act as reducing and capping agents. The formation of PN-AgNPs was confirmed by UV-Vis Spectroscopy which... Read More

The antiviral drug Molnupiravir (MOL) and its conjugate with Hyaluronic Acid (HA-MOL) demonstrate the significance of targeting the main protease (Mpro) and papain-like protease (PLpro) of SARS-CoV-2. The pure drug Molnupiravir and the designed polymer-drug conjugate using Molnupiravir and hyaluronic acid were evaluated through molecular docking, pharmacokinetic analysis, molecular dynamics... Read More

Marine organisms, particularly algae, have garnered significant attention due to their rich biodiversity and potential as sources of novel bioactive compounds. Among them, Caulerpa racemosa, a green alga commonly found in tropical marine environments has been recognized for its therapeutic potential, but its biological activities remain underexplored. The current study investigates the... Read More

Extensive plastic use across industries such as automotive, construction, and packaging has significantly contributed to environmental concerns. Understanding the sources of microplastic contamination in food and its associated health risks is crucial for minimizing exposure. As a result, this issue has gained attention due to its potential negative impact on human health. Food contamination... Read More

The research aims to establish a new UPLC method for estimating Tepotinib in human plasma. A simple, precise, and accurate RP-UPLC technique has been developed to quantify Tepotinib (TEP) in human plasma by employing a Quality by Design (QbD) approach. The effective separation of TEP was accomplished using the ACQUITY UPLC HSS C18 Column (1.8 µm, 2.1 mm×100 mm) and 0.01N Ammonium formate :... Read More

Dental caries, the most common chronic infectious disease in the oral cavity, affects around 3.5 billion individuals worldwide, with a particularly high prevalence in middle-income countries. Streptococcus mutans is a major cariogenic pathogen recognized for its ability to form biofilms that lead to tooth decay. Molecular docking studies showed stable interactions between lactotransferrin (LTF)... Read More